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Bodybuilders often take HGH in exogenous form to increase HGH production, increasing muscle mass and fat loss, and to suppress free fatty acid synthesis and lipid peroxidation. It has been estimated that exogenous HGH in the form of IGF-I or a combination of the two can be up to 5 times more potent than natural HGH in promoting growth of muscle mass and improving body composition.  It has been reported that exogenous GH stimulates muscle growth, increases fat-free mass, and improves fat oxidation and lean body mass, while the combined effects are more potent in both directions. The latter observation is particularly intriguing in view of the high expression of growth factors required for muscle growth and fat repair. The most important role of exogenous HGH in human health is in bodybuilding. It was first used in the 1960s and rapidly became a "must have" supplement for the human bodybuilder. Today it remains one of the most widely-used supplements in the bodybuilding industry, both in terms of popularity (the company claims that 30% of total US market) [3, 4]. Exogenous HGH for human health, as with many popular food supplements, has become a multimillion dollar a year business to the detriment of public health. Scientific evidence that HGH stimulates bodybuilding is based on the work of researchers at the National Institute of Health (NIH) in the 1960s. The NIH investigators measured growth factor-I and body composition in the bloodstream of 11 young men who each consumed a dose of HGH of 20–40 mg/day for up to six months. Blood samples were taken throughout the six-month studies, as well as at the end of the studies. Subjects were free of medical illnesses at the start of the studies, which were performed at the University of Kentucky School of Medicine. This was the first study to document the effects of HGH on body composition. The researchers found that HGH increased the amounts of total IGF-I by 2.2 percent, total IGF-dependent protein synthesis by 3.5 percent, and muscle IGFBP-3 by 6 percent in young men. These results were remarkably similar to those of a later study performed at the University of North Carolina School of Medicine (UNC-SUMC). In addition, the researchers also found that HGH increased lean body weight, body fat mass, and body fat, whereas the combined effects of HGH and IGF-I was more potent. Subjects taking HGH gained lean body mass and fat mass at the same rate, but those taking IGF- Similar articles: